VZV-specific Tissue Resident Memory T-cells After Shingrix Vaccination

Running, not enrolling · Phase 4

Conditions studied: Varicella Zoster Virus Infection

In brief

To evaluate the effect of intramuscular RZV vaccine on VZV-specific skin TRM and circulating T-cells

Key facts

Study ID

NCT04403139

Run by

University of Washington

People needed

50

Starts

2022-04-27

Expected to finish

2026-12-01

Last updated by the study team

2026-05-05

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Cohort 1: 30-40 years of age
• Cohort 2: 70 years of age or older
• HIV seronegative

You may not qualify if…

• Previous vaccination with Shingrix (RZV), Zostavax (ZVL, zoster vaccine live), or with the chickenpox vaccine
• VZV seronegative
• Active Hepatitis C infection or active Hepatitis B infection. Persons with serologic evidence of hepatitis C infection that has cleared spontaneously, or with a history of treated hepatitis C with a sustained virologic response, can be enrolled. Persons with a history of resolved hepatitis B infection (negative for hepatitis B surface antigen) can be enrolled
• History of a life-threatening allergic reaction (anaphylactic/anaphylactoid reaction) to any component of the vaccine
• History of receipt of an organ transplant or hematopoietic stem cell transplant
• Significant autoimmune disease such as rheumatoid arthritis, psoriatic arthritis, inflammatory bowel disease, multiple sclerosis, scleroderma, dermatomyositis, or other condition which in the past has required significant immune modifying medication or which has a clinical course that is characterized by relapses
• Has immunosuppression as a result of an underlying illness (e.g. leukemia, lymphoma or other malignant neoplasms) or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy.
• Has long-term use of oral or parenteral steroids (>7 days), or high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding 6 months (nasal and topical steroids are allowed)
• Women of child-bearing potential only: pregnant, breastfeeding, or planning to become pregnant 3 months post vaccination
• Has an acute or chronic medical condition that, in the opinion of the investigator, would render biopsies unsafe
• History of coagulopathy or taking medication that may cause bleeding (long term high dose aspirin, heparin, coumadin). Aspirin doses <100 mg daily allowed
• History of keloid formation or excessive scarring
• History of frequent cellulitis or boils (>3 episodes in past 2 years) requiring antibiotic therapy
• Allergy to lidocaine, silver nitrate, or mupirocin
• Has any condition or medical history that would, in the opinion of the site principal investigator place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol.

Where it is running

• University of Washington Virology Research Clinic — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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