Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone

Completed · Phase 4

Conditions studied: Post-operative Pain Control

In brief

Photorefractive keratectomy (PRK) is a refractive error correction procedure that helps eliminate or reduce the dependence on corrective lenses. An important aspect of PRK is post-operative pain management. Post-operative pain can be significant in the first three to five days and is typically controlled utilizing various modalities including narcotic pain medication. Simple observation suggests a difference in the post-operative pain levels of patients utilizing the more potent oxycodone- versus the less potent codeine-containing acetaminophen preparations. There have been no studies performed to explore any differences in perceived pain comparing these two medications when used following PRK. This study is designed to answer this question by means of a pain survey conducted in the first five days post-op. This may help better manage similar patients in the future.

Key facts

Study ID

NCT04399122

Run by

59th Medical Wing

People needed

200

Starts

2017-03-21

Expected to finish

2019-10-28

Last updated by the study team

2021-10-05

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• M/F >21 years of age (PRK is not done on anyone under the age of 21 at this surgery center)
• Have met all criteria for bilateral PRK

You may not qualify if…

• Patients who do not meet the criteria for refractive surgery
• Patients receiving LASIK
• Patients known to have an allergy to either of the study pain medications
• Patients receiving refractive surgery on only one eye
• Pregnant women, children, military basic trainees, prisoners and detainees
• Subject has used narcotics in the last 6 months

Where it is running

• Joint Warfighter Refractive Surgery Center at WHASC — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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