Effect of Whole Blueberry Powder Consumption on Depression in a Central Louisiana Population

Completed · Not applicable · Has a placebo group

Conditions studied: Depression, Depression, Anxiety, Inflammation

In brief

This pilot study aims to measure the effects of an intervention of 22.5 grams of freeze-dried whole blueberry powder in water drunk daily. Measures are on outcomes of depression, biological markers of inflammation and oxidative stress, and microbial populations in the intestines.

Key facts

Study ID

NCT04398784

Run by

Louisiana State University, Baton Rouge

People needed

45

Starts

2019-04-15

Expected to finish

2019-11-26

Last updated by the study team

2020-05-21

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants with a stable diagnosis of Major Depressive Disorder (>1 year prior to enrollment)
• Males and females 18-70 years of age
• Subjects with sleep disruptions
• Subjects currently prescribed to a non-antipsychotic mono-pharmacotherapies
• English speaking subjects only (all evaluations are in English)
• Subjects with the following inflammatory disorders that exhibit low to moderate symptoms:
• Hypertension (mild=140/80-160/90; moderate= 160/90-180/100)
• Asthma (requiring 2 or fewer inhalations of rescue inhaler per day)
• Gastroesophageal reflux disease
• Irritable bowel syndrome (controlled, <3 bowel movements a day)
• Arthritis (controlled)
• Chronic stomach ulcers (controlled)
• Obesity BMI <40
• Chronic pain
• Fibromyalgia
• Chronic Fatigue Syndrome
• Type I or Type II diabetes (controlled)
• Subjects that are compliant with current treatment regimens and clinic appointments
• Subjects taking intermittent or infrequent doses of acetaminophen or NSAIDs
• Subjects who currently smoke or have a history of smoking

You may not qualify if…

• Subjects with current diagnosis or history of the following conditions; or subjects currently on medication for any of the following conditions:
• Severe Cardiovascular disease; Heart attack/pacemaker
• Cancer
• Autoimmunity Disorders
• Crohn's Disease or Ulcerative Colitis
• Alzheimer's Disease
• Parkinson's Disease
• Multiple Sclerosis
• Uncontrolled Diabetes: Type I or II
• Severe irritable bowel disease (>3 stools per day)
• Hypertension (severe >180/100)
• Hypotension (<100/60)
• Epilepsy
• Autism Spectrum Disorder
• Schizophrenia
• Psychosis/Psychotic Symptoms
• Uncontrolled Hypo/Hyperthyroidism
• Women who are pregnant, nursing, lactating, or planning to become pregnant within timeline of study
• Subjects who are blind or deaf
• Subjects who are allergic to blueberries or other similar foods or drinks (e.g. wine), or subjects who are allergic to red or blue food dye agents
• Subjects who do not like the taste of blueberries
• Subjects who do not want to disclose information related to their Major Depressive Disorder
• Subjects who do not want to be subjected to blood draws
• Subjects who consume >4 cups of blueberries per week or other foods/drinks with significant polyphenol content
• Subjects supplementing with elderberry syrup >4 times per week

Where it is running

• Cottonport Family Clinic — Cottonport, Louisiana, United States
• Marksville Family Clinic — Marksville, Louisiana, United States

Full record on ClinicalTrials.gov

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