Ultra High Resolution CT to Assess Role of Intramyocardial Fat and Delayed Enhancement in Ventricular Arrhythmogenesis

Running, not enrolling

Conditions studied: Ventricular Arrhythmias

In brief

This research is being done to determine how well cardiac computed tomography (CT) scanning measures of fat within the heart can predict abnormal heart rhythms and how well cardiac CT can measure scar within the heart versus cardiac magnetic resonance imaging (MRI). * People who have been enrolled in PROSe-ICD (NA\_00045142) and Reynolds (NA\_00037404) studies may join * The procedures, tests, drugs or devices that are part of this research and will be paid for by the study

Key facts

Study ID

NCT04394637

Run by

Johns Hopkins University

People needed

110

Starts

2021-03-04

Expected to finish

2029-05-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18 or older with history of ischemic cardiomyopathy enrolled in the current Reynolds study or PROSe-ICD study will be asked to participate
• Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study CT
• Ability to understand and willingness to sign the Informed Consent Form

You may not qualify if…

• Known allergy to iodinated contrast media
• Patients with glomerular filtration rate (GFR) ≤ 30 mL/min will not be enrolled in the study due to the use of intravenous iodinated contrast agents
• Atrial fibrillation or uncontrolled tachyarrhythmia
• Evidence of severe symptomatic heart failure (NYHA Class III or IV)

Where it is running

• Johns Hopkins Medical Institute — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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