Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate

Recruiting now · Not applicable

Conditions studied: Cerebrovascular Circulation, Physiology

In brief

The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity. In order to manipulate heart rate, the investigators will recruit patients already scheduled for clinically indicated elective electrophysiological studies, where temporary pacing catheters placed in the right atrium can be used to artificially pace the heart at controlled rates. MCA CBF will be measured by transcranial Doppler ultrasound.

Key facts

Study ID

NCT04391465

Run by

University of Calgary

People needed

20

Starts

2021-08-11

Expected to finish

2027-12-01

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female
• Age 18-70 years, inclusive
• Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium
• Left ventricular ejection fraction ≥50%
• Able and willing to provide informed consent
• Able to travel to the Cardiac Electrophysiology Laboratory at the Foothills Medical Centre, Calgary, Alberta, Canada

You may not qualify if…

• Unable or unwilling to provide informed consent
• Other factors which in the investigator's opinion would prevent the participant from completing the protocol

Where it is running

• Foothills Medical Center — Calgary, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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