Cannabis Effects as a Function of Sex

Running, not enrolling · Phase 1 · Has a placebo group

Conditions studied: Pain, Abuse, Drug

In brief

The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women

Key facts

Study ID

NCT04385082

Run by

University of California, Los Angeles

People needed

160

Starts

2021-07-08

Expected to finish

2027-09-01

Last updated by the study team

2026-07-06

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or non-pregnant female aged 21-55 years
• Report use of cannabis an average of 1-7 days per week
• Not currently seeking treatment for their cannabis use
• Urine test positive for recent cannabis use for heavy users
• No reported adverse effects with cannabis smoking in light users
• Have a Body Mass Index from 18.5 - 34kg/m2.
• Able to perform all study procedures
• FEMALES: Currently practicing a non-hormonal effective form of birth control
• FEMALES: Must be regularly cycling

You may not qualify if…

• Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or cannabis use disorder
• Report using other illicit drugs in the prior 4 weeks
• History or current evidence of severe psychiatric illness or medical condition judged by the study physician and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
• Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
• Current pain
• Insensitivity to the cold water stimulus of the Cold Pressor Test
• FEMALES: using a hormonal contraceptive

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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