Radiation Therapy to Relieve Symptoms in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Completed · Phase 1

Conditions studied: Non-Small Cell Lung Cancer

In brief

This study will test the safety of Quad Shot radiation therapy using 2 different treatment schedules to find out what effects, if any, this treatment has on people with advanced NSCLC who are receiving systemic therapy for their cancer. The Quad Shot treatment schedule reduces the number of days needed to deliver the radiation treatments, which may be less disruptive to systemic therapy schedules.

Key facts

Study ID

NCT04384146

Run by

Memorial Sloan Kettering Cancer Center

People needed

41

Starts

2020-05-07

Expected to finish

2026-02-05

Last updated by the study team

2026-02-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed non-small cell lung cancer with metastatic disease detected on cross-sectional imaging with a plan for one of the following systemic therapies:
• Carboplatin/paclitaxel
• Carboplatin/paclitaxel/pembrolizumab
• Carboplatin/pemetrexed
• Carboplatin/pemetrexed/pembrolizumab
• Pembrolizumab (single agent or in combination with other regimens in this list)
• Cisplatin/pemetrexed
• Cisplatin/pemetrexed/pembrolizumab
• Pemetrexed/pembrolizumab
• Pemetrexed
• Nivolumab (single agent or in combination with other regimens in this list)
• Ipilimumab/nivolumab
• Carboplatin/etoposide
• Carboplatin/etoposide/atezolizumab
• Cisplatin/etoposide
• Cisplatin/etoposide/atezolizumab
• Durvalumab (single agent or in combination with other regimens in this list)
• Atezolizumab (single agent or in combination with other regimens in this list)
• Patients eligible for the systemic therapy regimens notes
• Patients with Stage IV NSCLC who have symptomatic (defined by patient-reported cough, dyspnea, or hemoptysis) or near-symptomatic (determined radiographically to be threatening the airway, esophagus or vasculature) centrally located.
• KPS ≥ 60
• Age ≥ 18 years.
• Able to provide informed consent.
• Patients at reproductive potential must agree to practice an effective contraceptive method.

You may not qualify if…

• Previous radiotherapy to the intended treatment site that precludes developing a treatment plan that respects normal tissue tolerances.
• Serious medical co-morbidities precluding radiotherapy.
• Pregnant or breast-feeding women.

Where it is running

• Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (All Protocol Activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (All protocol activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Commack (All protocol activities) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (All protocol activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Memorial Sloan Kettering Nassau (All protocol activities) — Rockville Centre, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.