Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency

Completed · Not applicable

Conditions studied: Parkinson Disease

In brief

Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function. Intervention: Patients' deep brain stimulators will be turned off or on and the frequency will be changed to either theta or gamma. Objectives: To identify differences in higher cognitive functions with stimulation "on" and "off" and theta versus gamma frequency stimulation. Study population: 12 patients who had previously undergone bilateral STN deep brain stimulation implantation. Study methodology: Patients will undergo four sessions of neuropsychological testing (RNGT, verbal fluency, D-KEFS CWIT) at baseline, no stimulation, theta stimulation and gamma stimulation, in random order over one day. Study outcomes: Test results of RNGT, verbal fluency, D-KEFS CWIT. Follow-up: none Statistics: Test results will be analyzed using within-subjects statistical tests.

Key facts

Study ID

NCT04383665

Run by

University of Southern California

People needed

12

Starts

2020-01-31

Expected to finish

2020-03-03

Last updated by the study team

2021-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patients who had previously undergone bilateral STN deep brain stimulation implantation
• Age >18 years old
• Stable medication regimen for at least 3 months.
• Patient informed and able to give written consent
• Able to comply with all testing, follow-ups and study appointments and protocols

You may not qualify if…

• History of epilepsy or seizure
• History of major substance abuse
• Patients with baseline settings at less than 1.5 V will be excluded from the study

Where it is running

• Keck hospital of the University of Southern California — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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