ASPIrin in Reducing Events in Dialysis ( ASPIRED )

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: CKD (Chronic Kidney Disease) Stage 5D

In brief

People with kidney failure requiring dialysis have a much higher risk of developing cardiovascular (CV) disease compared with the general population. A cardiac cause accounts for 58% of all deaths in patients with end stage kidney disease (ESKD). At the same time, this population has increased risks of clotting as well as bleeding episodes. While aspirin is known to reduce cardiovascular complications in the general population, evidence to support the use of aspirin in people with ESKD receiving dialysis therapy is currently lacking. The ASPIrin to Reduce Event in Dialysis (ASPIRED) trial will test whether aspirin use in dialysis patients safely improves outcomes compared with no aspirin use.

Key facts

Study ID

NCT04381143

Run by

Guangdong Provincial People's Hospital

People needed

9000

Starts

2020-07-30

Expected to finish

2026-12-01

Last updated by the study team

2025-11-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Incident or prevalent adults (≥18 years old) dialysis patients are included in the Dialysis Registry.
• Commenced on dialysis with the expectation of ongoing maintenance dialysis requirement.
• Willing and able to provide informed consent for this study.

You may not qualify if…

• Requirement for any form of antiplatelet agent (aspirin, glycoprotein IIb/IIIa inhibitors etc), or oral anticoagulation (warfarin, NOACs), in the view of the treating physician.
• Contraindication to aspirin, in the view of the treating physician.
• Dialysis requirement due to acute kidney injure with expectation of kidney function recovery.
• History of haemorrhagic stroke or intracranial bleed within 12 months of screening.
• Coagulopathy from any cause.
• Unable to provide informed consent.

Where it is running

• Guangdong Cliffod Hospital — Guangzhou, Guangdong, China (enrolling)
• Guangzhou First People's Hospital — Guangzhou, Guangdong, China (enrolling)
• Dongguan Donghua Hospital — Dongguan, Guangdong, China (enrolling)
• Guangdong Agricultural Reclamation Central Hospital — Guangzhou, Guangdong, China (enrolling)
• Guangdong Provincial Peoples Hospital — Guangzhou, Guangdong, China (enrolling)
• Dongguan Eighth People's Hospital — Dongguan, Guangdong, China (enrolling)
• Dongguan Marina Bay Center Hospital — Dongguan, Guangdong, China (enrolling)
• Dongguan People's Hospital — Dongguan, Guangdong, China (enrolling)
• Shanghang County Hospital — Longyan, Fujian, China (enrolling)
• The First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China (enrolling)
• The First Hospital of Lanzhou University — Lanzhou, Gansu, China (enrolling)
• The Second People Hospital of Foshan Nanhai — Foshan, Guangdong, China (enrolling)
• Foshan Nanhai District People's Hospital — Foshan, Guangdong, China (enrolling)
• Foshan No.1 people's hospital — Foshan, Guangdong, China (enrolling)
• Foshan Sanshui People's Hospital — Foshan, Guangdong, China (enrolling)
• Foshan Second People's Hospital — Foshan, Guangdong, China (enrolling)
• Guangdong Provincial Hospital of Integrative Medicine — Foshan, Guangdong, China (enrolling)
• The Third Affiliated Hospital of Southern Medical University — Guangzhou, Guangdong, China (enrolling)
• The First Affiliated Hospital of Guangdong Medical University — Guangzhou, Guangdong, China (enrolling)
• Sun Yat-sen Memorial Hospital — Guangzhou, Guangdong, China (enrolling)
• Guangzhou Redcross Hospital — Guangzhou, Guangdong, China (enrolling)
• Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China (enrolling)
• Foshan Gaoming District People's Hospital — Foshan, Guangdong, China (enrolling)
• The First Affiliated Hospital of Jinan University — Guangzhou, Guangdong, China (enrolling)
• Hua Du District People's Hospital of Guangzhou — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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