Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors

Completed · Phase 1

Conditions studied: Advanced Solid Tumor, Clear Cell Renal Cell Carcinoma, Hepatocellular Carcinoma, Non-small Cell Lung Cancer

In brief

This is a Phase 1/1b, open-label, first-in-human, dose-escalation and expansion study of CHS-388, a monoclonal antibody that targets IL-27, as a monotherapy and in combination in patients with solid tumors.

Key facts

Study ID

NCT04374877

Run by

Coherus Oncology, Inc.

People needed

145

Starts

2020-04-22

Expected to finish

2025-06-05

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• City of Hope — Duarte, California, United States
• University of Southern California (USC) - Norris Comprehensive Cancer Center — Los Angeles, California, United States
• UCSF Medical Center - Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• University of Miami Leonard M. Miller School of Medicine (UMMSM) — Miami, Florida, United States
• Moffitt Cancer Center — Tampa, Florida, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• University of Michigan Health System (UMHS) — Ann Arbor, Michigan, United States
• Washington University School of Medicine - St. Louis — St Louis, Missouri, United States
• Roswell Park — Buffalo, New York, United States
• Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH) — New York, New York, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Oklahoma Health Sciences Center (OUHSC) - Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
• University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center (University of Pittsburgh Cancer Institute (UPCI)) — Pittsburgh, Pennsylvania, United States
• Vanderbilt University Medical Center (VUMC) — Nashville, Tennessee, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States
• The University of Texas - MD Anderson Cancer Center — Houston, Texas, United States
• South Texas Accelerated Research Therapeutics — San Antonio, Texas, United States
• University of Washington — Seattle, Washington, United States
• National University Hospital — Singapore, Singapore
• National Cancer Center Singapore (NCCS) — Singapore, Singapore
• Seoul National University Hospital — Seoul, South Korea
• Severance Hospital — Seoul, South Korea
• Asan Medical Center — Seoul, South Korea

Full record on ClinicalTrials.gov

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