The Rhode Island Prescription and Illicit Drug Study

Completed · Not applicable

Conditions studied: Opioid Overdose, Drug Overdose

In brief

This study will test the efficacy of a novel drug-checking intervention to prevent fatal and non-fatal overdose among people who use drugs (PWUD), who are 18-65 years old at the time of enrollment. The investigators will evaluate whether the incorporation of rapid fentanyl testing into a theory-driven overdose education and prevention intervention reduces rates of overdose compared to standard overdose education and naloxone distribution. Results from this study will significantly improve public health efforts to address the fentanyl overdose epidemic and reduce harms associated with exposure to drugs contaminated with fentanyl. This is a full clinical trial, building on the previously approved fentanyl-test-strip pilot study (2016-2017), the results of which have recently been published.(Krieger et al., 2018)

Key facts

Study ID

NCT04372238

Run by

Brown University

People needed

509

Starts

2020-08-31

Expected to finish

2024-02-29

Last updated by the study team

2025-08-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Reside in Rhode Island
• Are able to complete interviews in English
• Are able to provide informed consent
• Self-report past 30 day heroin, illicit stimulants, counterfeit prescription pills, or injection drugs

You may not qualify if…

• Participants who exclusively misuse medications obtained from a physician or diversion from someone else's prescription

Where it is running

• Brown University School of Public Health — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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