Genetics of COVID-19 Susceptibility and Manifestations
Completed
Conditions studied: COVID-19, Coronavirus 2019
In brief
Background: Coronavirus 2019 (COVID-19, or SARS-CoV-2) is a serious public health problem, and genetics may play a role in how serious the illness becomes in certain people. Genes are the instructions that our body uses to grow and develop. Variations in our genes can cause medical conditions and may be the reason why some people get sicker than others. Objective: This study aims to learn more about the genetic contributions to the severity of COVID-19. We hope to use this information to develop therapies that reduce the severity of COVID-19 symptoms in some people. Eligibility: Anyone located in the United States who has tested positive for SARS-CoV-2 infection may be eligible to join (including NIH staff). Design: Participants will complete a questionnaire about their health history and COVID-19 symptoms. Participants will give a blood or saliva sample. It will be about 2 tablespoons of blood, or we will send a saliva collection kit. Researchers will use this blood or saliva sample to study the participant s DNA. The data about participants genes will be stored in a large database. The database will be shared with other qualified researchers who are trying to learn about COVID-19. Participants names and other personal details will not be shared. Instead, the data will be labeled with a code. Participants may be contacted by study team members for up to a year after they join the study.
Key facts
- Study ID
- NCT04371432
- Run by
- National Human Genome Research Institute (NHGRI)
- People needed
- 721
- Starts
- 2020-05-05
- Expected to finish
- 2024-12-15
- Last updated by the study team
- 2026-07-27
Who can join
Age: 0 and older, up to 110. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Individuals for whom we cannot consent for participation in a language offered by our existing interpretation service.
- Weight less than 10 kg*
Where it is running
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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