CONFIRM: Magnetic Resonance Guided Radiation Therapy

Recruiting now · Not applicable

Conditions studied: Gastric Cancer, Invasive Breast Cancer, in Situ Breast Cancer, Mantle Cell Lymphoma, Larynx Cancer, Bladder Cancer

In brief

This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer. The name of the radiation machine involved in this study is the MRIdian Linear Accelerator.

Key facts

Study ID

NCT04368702

Run by

Brigham and Women's Hospital

People needed

70

Starts

2021-05-01

Expected to finish

2029-06-18

Last updated by the study team

2026-02-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must have histologically or cytologically confirmed malignancy requiring radiation
• Age 18 years of older
• ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
• Ability to understand and the willingness to sign a written informed consent document.
• Any further criteria listed in the specific disease site cohort

You may not qualify if…

• History of allergic reactions attributed to gadolinium-based IV contrast
• - Note: If patient will not receive contrast, this is not applicable and kidney function will not affect eligibility
• Severe claustrophobia or anxiety
• Participants who cannot undergo an MRI
• Any other exclusion criteria listed in the specific disease site cohort

Where it is running

• Brigham & Women's Hospital — Boston, Massachusetts, United States (enrolling)
• Dana Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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