Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19
Stopped early · Phase 1/Phase 2
Conditions studied: Pneumonia, Coronavirus Infection in 2019 (COVID-19), Severe Acute Respiratory Syndrome (SARS) Pneumonia
In brief
This phase I/II trial studies low-dose radiation therapy as a focal anti-inflammatory treatment for patients with pneumonia or SARS associated with COVID-19 infection.
Key facts
- Study ID
- NCT04366791
- Run by
- Emory University
- People needed
- 47
- Starts
- 2020-04-24
- Expected to finish
- 2022-03-11
- Last updated by the study team
- 2022-03-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Have had a positive test confirming the diagnosis of COVID-19
- Have had clinical signs of severe acute respiratory syndrome or pneumonia (dyspnea, cough, with need for oxygen support at the time of enrollment)
- Have visible consolidations/ground glass opacities on chest x-ray or computed tomography
- Have received pre-intubation respiratory support or undergone endotracheal intubation and have been on ventilator support for no longer than 5 (five) calendar days prior to the schedule date of delivery of low-dose radiation therapy.
- Willingness and ability of the subject to comply with scheduled visits, protocol-specified laboratory tests, other study procedures, and study restrictions
- Evidence of a signed informed consent/assent indicating that the subject is aware of the infectious nature of the disease and has been informed of the procedures to be followed, potential risks and discomforts, potential benefits, and other pertinent aspects of study participation
You may not qualify if…
- No use of disallowed medications 1 day prior to delivery of LDRT: Azithromycin, chloroquine, hydrochloroquine, COVID-targeted antiviral medications
- Pregnant and/or planned to be pregnant within in next 6 months
Where it is running
- Emory University Hospital Midtown/Winship Cancer Institute — Atlanta, Georgia, United States
- Emory Saint Joseph's Hosptial — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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