CONTAIN COVID-19: Convalescent Plasma to Limit COVID-19 Complications in Hospitalized Patients

Completed · Phase 2 · Has a placebo group

Conditions studied: COVID-19, Coronavirus, Coronavirus Infection

In brief

This is a randomized, blinded phase 2 trial that will assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with acute respiratory symptoms requiring oxygen supplementation.

Key facts

Study ID

NCT04364737

Run by

NYU Langone Health

People needed

941

Starts

2020-04-17

Expected to finish

2022-12-12

Last updated by the study team

2023-01-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥18 years of age
• Hospitalized with laboratory confirmed COVID-19
• One or more of the following respiratory signs or symptoms: cough, chest pain, shortness of breath, fever, oxygen saturation ≤ 94%, abnormal CXR/CT imaging)
• Hospitalized for ≤ 72 hours OR within day 3 to 7 days from first signs of illness
• On supplemental oxygen, non-invasive ventilation or high-flow oxygen
• Patients may be on other randomized controlled trials of pharmaceuticals for COVID -19 and patients who meet eligibility criteria will not be excluded on this basis.

You may not qualify if…

• Receipt of pooled immunoglobulin in past 30 days
• Contraindication to transfusion or history of prior reactions to transfusion blood products
• Invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO)
• Volume overload secondary to congestive heart failure or renal failure
• Unlikely to survive past 72 hours from screening based on the assessment of the investigator
• Unlikely to be able to assess and follow outcome due to poor functional status

Where it is running

• Yale University School of Medicine — New Haven, Connecticut, United States
• University of Miami Hospital and Clinics — Miami, Florida, United States
• NYU Langone Health — New York, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• University of Texas Rio Grande Valley — Edinburg, Texas, United States
• The University of Texas Health Science Center — Houston, Texas, United States
• The University of Texas Health Science Center — Tyler, Texas, United States
• Aurora St. Luke's Medical Center — Milwaukee, Wisconsin, United States
• Medical College of Wisconsin / Froedtert Memorial Lutheran Hospital — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.