Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP)
Status unconfirmed · Phase 3 · Has a placebo group
Conditions studied: COVID-19, Corona Virus Infection, Wuhan Coronavirus, Prophylaxis, Healthcare Worker, Sars-CoV2, Hydroxychloroquine
In brief
This a double-blind, randomized, placebo-controlled clinical trial to determine if primary prophylaxis with hydroxychloroquine in healthcare workers reduces symptomatic COVID-19 infection. Healthcare workers will be randomized at a 1:1 allocation between intervention and placebo arms and followed for 12 weeks. This study will enroll up to 1,700 participates in Lafayette, Louisiana. The primary outcome will number of symptomatic COVID-19 infections. Secondary endpoints included number of days healthcare workers are absent from work and rate of severe infection.
Key facts
- Study ID
- NCT04363450
- Run by
- Louisiana State University Health Sciences Center in New Orleans
- People needed
- 1700
- Starts
- 2020-04-27
- Expected to finish
- 2021-06-01
- Last updated by the study team
- 2020-09-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age ≥ 18 years
- Healthcare or Hospital Worker who has direct patient contact
- Willing to participate in the research.
- Able to understand and sign the informed consent form
You may not qualify if…
- Age < 18 years
- History of ventricular arrhythmia or use of Class IA, IC and III anti-arrhythmics
- Known prolonged QTc interval
- History of retinal disease
- Kidney failure with GFR <10%
- Chronic hepatic disease w/ Child-Pugh class B or C
- Hypersensitivity to chloroquine or hydroxychloroquine
- Currently taking chloroquine or hydroxychloroquine
- Unwilling to participate
- Unable to understand and/or sign the informed consent form.
Where it is running
- Lafayette General Medical Center — Lafayette, Louisiana, United States (enrolling)
- University Hospital and Clinics — Lafayette, Louisiana, United States (enrolling)
Full record on ClinicalTrials.gov
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