Investigation of the B- and T-cell Repertoire and Immune Response in Patients With Acute and Resolved COVID-19 Infection
Completed
Conditions studied: COVID-19
In brief
Background: People who get infected with COVID-19 have an unpredictable risk to worsen and die. This makes it hard to decide who can quarantine at home and who should be treated at a hospital. Researchers think the risk may be related to how a person s B and T cells respond to the virus. B and T cells are the major components of a person s immune response. B and T cells responding to the virus with a favorable pattern may lead to recovery, and this favorable pattern may be helpful to establish. If people in a vaccine trial get this same favorable pattern when responding to a vaccine, this may be a useful early signal that the vaccine will be successful. Objective: To examine how immune cells respond to COVID-19 infection. Eligibility: Adults ages 18 and older who have a confirmed or suspected COVID-19 infection or had COVID-19 in the past. Also, healthy donors with no suspected COVID-19 infection Design: Participants will be screened with medical record review. Participants will be tested with a research assay to determine who was infected with COVID-19 and who was not. This test will be used to understand research results, not to advise patients. Participants with active infection must be isolated, usually in a hospital. Other participants may give blood samples at NIH or at their local doctor s office or lab. Participants may give blood samples up to three times a week for a total of ten times, and may also give blood samples after starting a vaccine trial. Participants will be contacted by phone or email every 2 months for up to 2 years.
Key facts
- Study ID
- NCT04362865
- Run by
- National Cancer Institute (NCI)
- People needed
- 679
- Starts
- 2020-04-27
- Expected to finish
- 2025-02-10
- Last updated by the study team
- 2025-03-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- Medstar Washington Hospital Center — Washington D.C., District of Columbia, United States
- Medstar Franklin Square Medical Center — Baltimore, Maryland, United States
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States
- Medstar Montgomery Medical Center — Olney, Maryland, United States
Full record on ClinicalTrials.gov
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