Igniting Mobility in Adolescents and Young Adults With Cerebral Palsy

Running, not enrolling · Not applicable

Conditions studied: Cerebral Palsy

In brief

The study design will consist of a cohort of adolescents and young adults with cerebral palsy (CP) that will undergo a gait training protocol. All participants will complete MEG or EEG baseline brain imaging measures of their sensorimotor cortical activity, MRI brain/spinal cord imaging (previous MRI or template brain may be substituted), neurophysiological tests of the spinal cord H-reflex, and a series of mobility clinical tests and cognitive tests. Participants with metal in their body that would interfere with the MEG (e.g., braces on teeth, permanent retainer) will not undergo the MEG tests but will undergo the EEG assessments. Those who complete the MEG assessments will not undergo the EEG assessments. After completing the baseline tests, the participants with CP will undergo the therapeutic gait training. After completing all of the therapeutic gait training sessions, the participants with CP will repeat the same assessments that were completed at baseline. Separately, a cohort of neurotypical adolescents and young adults will also complete the baseline assessments. The neurotypical participants will not undergo the therapeutic gait training, but will be used as a normative group for interpreting if the changes seen in the participants with CP after therapy are in fact moving the system toward a normative state.

Key facts

Study ID

NCT04360395

Run by

Father Flanagan's Boys' Home

People needed

120

Starts

2020-08-03

Expected to finish

2027-05-31

Last updated by the study team

2026-07-30

Who can join

Age: 13 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For Cerebral Palsy participants:
• Cerebral Palsy diagnosis
• For Non-Cerebral Palsy Controls:
• No known atypical neurodevelopment (e.g autism, Down Syndrome, ADHD, etc.)

You may not qualify if…

• No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI.

Where it is running

• Boys Town National Research Hospital — Boys Town, Nebraska, United States

Full record on ClinicalTrials.gov

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