Efficacy of Inhaled Cannabis for Acute Migraine Treatment
Completed · Phase 2 · Has a placebo group
Conditions studied: Migraine, Cannabis, THC, CBD
In brief
This crossover study will evaluate 3 different treatments of vaporized cannabis (THC, THC/CBD mix, and CBD) and vaporized placebo cannabis for the acute treatment of migraine.
Key facts
- Study ID
- NCT04360044
- Run by
- University of California, San Diego
- People needed
- 92
- Starts
- 2020-11-20
- Expected to finish
- 2023-02-23
- Last updated by the study team
- 2023-02-28
Who can join
Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 21 and ≤ 65
- Able to communicate in English
- Migraine, with or without aura, in its episodic or chronic manifestations, as per the International Headache Society (IHS) classification International Classification of Headache Disorders (ICHD-3) criteria (section 1.1, 1.2, 1.3).(48)
- Ability to provide informed consent and complete website questionnaires in English
- Agrees not to use cannabis outside of the study during participation in the study
- Agrees not to use opioids or barbiturates during participation in the study
- Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study
You may not qualify if…
- Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone prior to enrollment
- Pregnancy
- Breastfeeding
- Prisoner
- Known cognitive impairment
- Institutionalized
- Current moderate-severe or severe depression
- Current or past history of bipolar depression, schizophrenia, or psychosis
- Current or past history of cannabis, alcohol, opioid, or amphetamine abuse or other substance use disorder at the discretion of the research team
- Active pulmonary disease class IV heart failure, cirrhosis, or other severe medical illnesses at the discretion of the research team.
- Allergy or past adverse effects or negative past experiences from cannabis
Where it is running
- Center for Pain Medicine, UC San Diego — La Jolla, California, United States
Full record on ClinicalTrials.gov
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