BFRT for Severe Lower Extremity Muscle Atrophy

Completed · Not applicable

Conditions studied: Severe Muscle Atrophy, Muscle Weakness

In brief

Muscle weakness or atrophy is a common condition following acute and chronic musculoskeletal injuries. Strength training is an imperative component in clinical rehabilitation of musculoskeletal injuries. Heavy exercise loads (approximately 70% of one repetition maximum) is necessary to elicit muscle hypertrophy and strength gains. However, patients with severe muscle atrophy are frequently unable to tolerate these loads due to pain. Blood flow resistance training with low resistance loads may be used to safely develop muscle strength.

Key facts

Study ID

NCT04357184

Run by

Cincinnati Sportsmedicine Research and Education Foundation

People needed

100

Starts

2020-04-14

Expected to finish

2022-02-15

Last updated by the study team

2022-02-16

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with > 20% deficit in isometric quadriceps and/or hamstrings strength
• Patients willing to complete at least 9 BFRT training sessions
• Patients willing to provide informed consent (or parental consent)

You may not qualify if…

• Pregnancy
• History of varicose veins
• History of blood clots or active blood clot
• Taking oral contraceptives
• History of heart attack
• Unstable cardiac disease
• Taking heart failure medication
• Uncontrolled hypertension (> 140/90)
• Uncontrolled tachycardia (> 100 bpm)

Where it is running

• Cincinnati Sportsmedicine and Orthopaedic Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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