The Acute Burn ResUscitation Multicenter Prospective Trial

Completed · Not applicable

Conditions studied: Burn Injury

In brief

This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.

Key facts

Study ID

NCT04356859

Run by

American Burn Association

People needed

101

Starts

2021-04-22

Expected to finish

2025-09-29

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Total burn size (second and third degree) is ≥ 25% of the TBSA
• Burn center admission within 12 hours of injury.
• There is a plan for formal fluid resuscitation.

You may not qualify if…

• Significant associated trauma
• High voltage (≥ 1000 volts) electrical burns
• Burn wound excision surgery within 48 hours from injury
• Fresh frozen plasma (FFP) given at any time ≤ 48 hours from injury
• Hypertonic saline (HTS) given at any time ≤ 48 hours from injury
• Hydroxyethyl starch (HES) given at any time ≤ 48 hours from injury
• High dose Vitamin C infusion given at any time ≤ 48 hours from injury
• Administration of human albumin prior to randomization
• Palliative comfort measures are instituted ≤ 48 hours from injury
• Pregnancy
• Pre-injury chronic renal insufficiency equal to or greater than stage 3
• Pre-injury chronic hepatic disease (Child-Pugh B or C)
• Pre-injury left ventricular (LV) dysfunction (echocardiography LV grade II-IV or ejection fraction ≤ 35%)

Where it is running

• Arizona Burn Center Valleywise Health — Phoenix, Arizona, United States
• University of California Davis, Regional Burn Center — Sacramento, California, United States
• Torrance Memorial — Torrance, California, United States
• University of Florida Health — Gainesville, Florida, United States
• University of Miami Health System — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Loyola Medicine — Maywood, Illinois, United States
• University of Iowa Healthcare — Iowa City, Iowa, United States
• University of Kansas Health System — Kansas City, Kansas, United States
• Ascension Via Christi St. Francis — Wichita, Kansas, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Hennepin Healthcare — Minneapolis, Minnesota, United States
• Cooperman Barnabas Medical Center — Livingston, New Jersey, United States
• Erie County Medical Center — Buffalo, New York, United States
• Westchester Medical Center Health Network — Valhalla, New York, United States
• Atrium Health Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States
• University of Cincinnati College of Medicine — Cincinnati, Ohio, United States
• Metrohealth Medical Center — Cleveland, Ohio, United States
• Legacy Health — Portland, Oregon, United States
• West Penn Hospital — Pittsburgh, Pennsylvania, United States
• The University of Tennessee Health Science Center — Memphis, Tennessee, United States
• University of Utah Health — Salt Lake City, Utah, United States
• Regional Burn Center at Harborview — Seattle, Washington, United States
• University of Wisconsin Health — Madison, Wisconsin, United States
• University of Alberta — Edmonton, Alberta, Canada

Full record on ClinicalTrials.gov

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