(KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit
Completed · Not applicable
Conditions studied: Metabolism, Protein
In brief
The specific hypothesis is that the consumption of 2 Hayward green kiwifruit (containing actinidin protease) prior to 100g of ground beef will increase the rate of protein digestion from the beef in the elderly, leading to an increased uptake of the essential amino acids. Furthermore, this increased essential amino acid availability will produce a greater postprandial net anabolic protein response, as well as increased fractional synthetic rates of muscle proteins.
Key facts
- Study ID
- NCT04356573
- Run by
- University of Arkansas
- People needed
- 13
- Starts
- 2018-07-01
- Expected to finish
- 2018-11-20
- Last updated by the study team
- 2021-11-04
Who can join
Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- men and women ages 60-85 inclusive.
You may not qualify if…
- Inability to chew meats or difficulty swallowing solid foods
- History of diabetes
- History of malignancy in the 6 months prior to enrolment
- History of gastrointestinal reduction or bypass surgery (Lapband, etc)
- History of a chronic inflammatory condition or disease (Lupus, HIV'AIDS, etc)
- History of chronic kidney disease or currently requiring dialysis.
- Allergy to beef or kiwifruit
- Subjects who do not or will not eat animal proteins
- Subjects who cannot refrain from consuming protein or amino acid supplements during their participation in this study
- Subjects who report regular resistance exercise (more than once per week)
- Hemoglobin less than 9.5mg/dL at the screening visit
- Platelets less than <150,000 at the screening visit
- Subjects who are not willing or able to suspend aspirin for several days prior to their muscle biopsies.
- Subjects who have been prescribed a blood-thinning medication (Coumadin, lovenox, heparin, Plavix, etc).
- Concomitant use of corticosteroids (ingestion, injection or transdermal)
- Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician
Where it is running
- UAMS Center on Aging — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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