Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain

Stopped early · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Injection Site Irritation, Pain

In brief

The primary hypothesis is that esmolol and lidocaine, when given without the use of a tourniquet, provide relief of propofol injection pain that is superior to placebo when assessed using the propofol pain scoring tool

Key facts

Study ID

NCT04356352

Run by

Wake Forest University Health Sciences

People needed

33

Starts

2020-09-09

Expected to finish

2023-08-25

Last updated by the study team

2024-09-19

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-60 years of age
• ASA 1-3
• Elective surgical procedure

You may not qualify if…

• BMI ≥ 45
• Pregnancy
• Requirement for RSI or awake intubation
• Suspected or known difficult airway
• Contraindication to IV in either upper extremity
• Chronic pain syndrome including fibromyalgia
• Use of opioids, NSAIDs, or other analgesics within 24 hours (including preoperative PO Celebrex, Lyrica, Tylenol, etc.)
• Any use of opioids in the past three months
• Significant cardiopulmonary or hepatic dysfunction
• Hypersensitivity to study medications

Where it is running

• Wake Forest Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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