SOLIRIS® (Eculizumab) Treatment of Participants With COVID-19

NO_LONGER_AVAILABLE

Conditions studied: COVID-19, Pneumonia, Viral, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

In brief

This protocol provides access to eculizumab treatment for participants with severe COVID-19.

Key facts

Study ID

NCT04355494

Run by

Alexion Pharmaceuticals, Inc.

Last updated by the study team

2021-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females ≥ 18 years of age and ≥ 40 kg at the time of providing informed consent.
• Confirmed diagnosis of SARS-CoV-2 infection presenting as severe COVID-19 requiring hospitalization
• Symptomatic, bilateral pulmonary infiltrates confirmed by CT or X-ray at Screening or within the 7 days prior to Screening
• Severe pneumonia, acute lung injury, or ARDS requiring oxygen supplementation

You may not qualify if…

• Confirmed diagnosis of SARS-CoV-2 infection presenting as mild to moderate COVID-19, even if the participant is hospitalized
• Participant is not expected to survive more than 24 hours
• Participant has an unresolved Neisseria meningitidis infection
• Hypersensitivity to murine proteins or to one of the excipients of Soliris

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Boston Medical Center — Boston, Massachusetts, United States
• Newton-Wellesley Hospital — Newton, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Robert Wood Johnson University Hospital — New Brunswick, New Jersey, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States
• The Ohio State University Wexner Medical Center — Columbus, Ohio, United States
• Hôpital Henri Mondor — Créteil, France
• Hôpital Garches Raymond Poincaré — Garches, France
• Hôpital de Bicêtre — Le Kremlin-Bicêtre, France
• Hôpital Saint Louis — Paris, France
• Hôpital Paul Brousse — Villejuif, France

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.