Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)

Running, not enrolling · Not applicable

Conditions studied: Cognitive Rehabilitation, ICU Survivorship, Intensive Care Unit, ICU

In brief

Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI). ICU-LTCI causes considerable problems with personal relationships, return to work, and everyday tasks, such as managing medicines and money. No treatment for these patients is currently available. Technology using computerized cognitive rehabilitation could improve ICU-LTCI by harnessing the healing potential of the brain (i.e., neuroplasticity). This intervention is scalable, portable, and economical. The investigators will evaluate the effectiveness of computerized cognitive rehabilitation in a randomized controlled trial of 160 ICU survivors. The investigators hypothesize that this intervention could improve cognition. This research has high potential to influence rehabilitation strategies for Veteran and civilian ICU survivors.

Key facts

Study ID

NCT04353804

Run by

VA Office of Research and Development

People needed

160

Starts

2022-10-03

Expected to finish

2027-07-31

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults with a recent ICU stay (Medical or Surgical) requiring treatment for respiratory failure and/or shock (i.e., high-risk population)
• No longer requiring ICU-level care

You may not qualify if…

• History of pre-existing severe cognitive impairment (IQCODE>=3.8 or documentation in medical record)
• Unwilling to commit to participation in the intervention
• Under consideration for hospice
• Primary residence over 100 miles from enrolling site if the patient is unwilling to return to the enrolling site for follow-up
• Homeless without a secondary contact available
• Severe substance abuse or neuropsychiatric disorder of a severity that prevents independent living
• Active suicidal ideation
• Any past or present behavior that may be deemed a safety risk for follow-up
• Blind, deaf, or unable to understand/communicate in English
• Required ICU level care less than 24 hours
• Not capable of completing computer-based training
• Co-enrollment in another study
• Incarcerated

Where it is running

• Tennessee Valley Healthcare System Nashville Campus, Nashville, TN — Nashville, Tennessee, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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