Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors or With Liver Metastases of Solid Tumors
Stopped early · Phase 1
Conditions studied: Cancer, Melanoma, Solid Tumor, Squamous Cell Carcinoma of Head and Neck, Breast Cancer, Advanced Solid Tumor, Triple Negative Breast Cancer, Colorectal Carcinoma, Non-melanoma Skin Cancer, Liver Metastases
In brief
ONCR-177-101 is a phase 1, open-label, multi-center, dose escalation and expansion study of ONCR-177, an oncolytic Herpes Simplex Virus for intratumoral injection, alone and in combination with PD-1 blockade in adult subjects with advanced and/or refractory cutaneous, subcutaneous or metastatic nodal solid tumors or with Liver Metastases of Solid Tumors. The purpose of this study is to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as well as to evaluate preliminary efficacy.
Key facts
- Study ID
- NCT04348916
- Run by
- Oncorus, Inc.
- People needed
- 66
- Starts
- 2020-05-20
- Expected to finish
- 2023-05-31
- Last updated by the study team
- 2023-06-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope — Duarte, California, United States
- Sarah Cannon Research Institute at HealthONE — Denver, Colorado, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Emory University — Atlanta, Georgia, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- The Ohio State University Wexner Medical Center James Cancer Hospital — Columbus, Ohio, United States
- Sarah Cannon Research Institute - Tennessee Oncology — Nashville, Tennessee, United States
- The University of Texas at Austin — Austin, Texas, United States
- University Health Network, Princess Margaret Cancer Centre — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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