Implementation Strategies for Monitoring Adherence in Real Time
Running, not enrolling · Not applicable
Conditions studied: Lung Cancer, Medication Adherence, Symptoms and Signs
In brief
The objective of this project is to identify effective strategies to help patients with lung cancer manage side effects and achieve optimal adherence to oral targeted therapies. To achieve this objective, we will evaluate the effect of a novel, bidirectional conversational agent, compared to usual care, on adherence to oral targeted therapies using a two-arm randomized controlled trial, and explore how multilevel factors impact the acceptability and effectiveness of this strategy by collecting qualitative and quantitative data from clinicians and patients.
Key facts
- Study ID
- NCT04347161
- Run by
- Abramson Cancer Center at Penn Medicine
- People needed
- 75
- Starts
- 2021-02-22
- Expected to finish
- 2026-10-16
- Last updated by the study team
- 2026-03-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patient (age > 18 years) with NSCLC at UPHS who is receiving one of the following nine oral therapies: afatinib, erlotinib, dacomitinib, gefitinib, osimertinib, alectinib, brigatinib, crizotinib, or lorlatinib.
- Patient possession of a mobile device that can send/receive SMS texts
- Ability to respond to questions and engage with "Penny" in English
- Ability to provide informed consent to participate in the study
- Approval from the patient's medical oncologist to be approached
You may not qualify if…
- Inability to respond to questions and engage with "Penny" in English
- Inability or unwillingness to provide informed consent to participate in the study
- Inability to engage with SMS text-messaging platform
- Concurrent enrollment in a therapeutic clinical trial
- Taking more than one oral targeted therapy or concurrent chemotherapy during the study window
- Lack of approval from the patient's oncologist
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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