A Study of LY3127804 in Participants With COVID-19

Stopped early · Phase 2 · Has a placebo group

Conditions studied: COVID-19, Pneumonia

In brief

A randomized, double-blind, placebo-controlled, clinical trial of LY3127804 in participants who are hospitalized with pneumonia and presumed or confirmed COVID-19.

Key facts

Study ID

NCT04342897

Run by

Eli Lilly and Company

People needed

95

Starts

2020-04-20

Expected to finish

2020-10-12

Last updated by the study team

2021-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Are hospitalized with pneumonia, and presumed or confirmed COVID-19
• Are able and willing to give signed informed consent (legally authorized representative can provide informed consent if needed)

You may not qualify if…

• Female participants must not be pregnant and/or lactating
• Have Acute Respiratory Distress Syndrome (ARDS) or will require immediate intermittent mandatory ventilation (IMV), or are ineligible for IMV
• Have any concurrent serious medical condition (for example dialysis) or concomitant medication that would preclude participation in the study
• Are moribund irrespective of the provision of treatments
• Have a known history or show evidence of human immunodeficiency virus (HIV) and/or hepatitis
• Have recently undergone major surgery or central venous access device placement
• Have a significant bleeding disorder or active vasculitis
• Have experienced a thromboembolic event
• Have symptomatic congestive heart failure, or symptomatic or poorly controlled cardiac arrhythmia
• Have a serious, nonhealing wound, peptic ulcer, or bone fracture
• Have liver cirrhosis
• Have a known sensitivity to monoclonal antibodies (mAbs) or other therapeutic proteins
• Have a history of hypertensive crisis or hypertensive encephalopathy or current, poorly controlled hypertension

Where it is running

• Banner Univ Med Ctr Phoenix — Phoenix, Arizona, United States
• Banner Univ Med Ctr Tucson — Tucson, Arizona, United States
• National Jewish Medical and Research Center — Denver, Colorado, United States
• Nuvance Danbury Hospital — Danbury, Connecticut, United States
• NorthShore University HealthSystem — Evanston, Illinois, United States
• Parkview Research Center — Fort Wayne, Indiana, United States
• Franciscan St. Francis Health — Indianapolis, Indiana, United States
• Ochsner Clinic Foundation — New Orleans, Louisiana, United States
• Lahey Hospital and Medical Center — Burlington, Massachusetts, United States
• Henry Ford Hospital Detroit — Detroit, Michigan, United States
• Allina Hospital Network — Minneapolis, Minnesota, United States
• State University of New York Hospital — Syracuse, New York, United States
• East Carolina University — Greenville, North Carolina, United States

Full record on ClinicalTrials.gov

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