Effects of High-Intensity Interval Training Exercise in Adolescents With Hepatosteatosis

Completed · Not applicable

Conditions studied: Non-Alcoholic Fatty Liver Disease, Insulin Resistance, High Intensity Interval Training, Childhood Obesity

In brief

This is a research study about how short-term exercise intervention affects adolescents with a disease called non-alcoholic fatty liver disease (NAFLD).

Key facts

Study ID

NCT04342390

Run by

Arkansas Children's Hospital Research Institute

People needed

40

Starts

2021-04-02

Expected to finish

2022-11-01

Last updated by the study team

2024-08-22

Who can join

Age: 13 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Pre-pubertal or early stages of puberty
• Pregnancy
• Confirmed lack of NAFLD in the past 6 months via biopsy or MRI
• Presence of an implantable medical device or metal objects in the body (a contraindication for FibroScan and/or MRI)
• High-risk to participate in an exercise program as determined by "The Physical Activity Readiness Questionnaire for Everyone"
• Unable to cooperate with study procedures and tests including genetic or physical conditions impacting mobility over the past year
• Having known chronic illnesses/disorders that may independently affect study outcome measures: type 1 diabetes mellitus, type 2 diabetes, neurologic (e.g., epilepsy), developmental (developmental delay, autism spectrum disorder), endocrine (Cushing's, growth hormone deficiency), hepatic (other than NAFLD), autoimmune, cardiac and renal disorders
• Current history of poorly-controlled asthma.
• Taking any of the following medications that can affect study outcome at the time of enrollment: insulin, metformin, or any other anti-diabetics, antipsychotics, oral steroids, and anabolic drugs (growth hormone replacement therapy, testosterone, and oxandrolone).
• Adolescents who have a history of claustrophobia.
• Adolescents who need sedation in order to complete MRI.
• Adolescents determined ineligible by the study investigator or delegated staff.

Where it is running

• Arkansas Children's Nutrition Center — Little Rock, Arkansas, United States
• Arkansas Children's Pediatric Clinical Research Unit — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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