Effects of DPP4 Inhibition on COVID-19

Withdrawn before enrolling · Phase 4

Conditions studied: Coronavirus Infection, Type 2 Diabetes

In brief

The purpose of this research is to see if the DPP4 inhibitor linagliptin, an oral medication commonly used to treat type 2 diabetes,can help with diabetes control and reduce the severity of the COVID-19 infection

Key facts

Study ID

NCT04341935

Run by

University of Miami

People needed

0

Starts

2021-06-30

Expected to finish

2021-12-30

Last updated by the study team

2021-06-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 Diabetes Mellitus (T2DM) as per American Diabetes Association (ADA) guidelines
• Age ≥ 18
• Confirmed COVID-19
• Mild COVID-19 defined as any of the following: fever, malaise, cough, headache, sore throat, myalgia, nasal congestion, diarrhea
• Moderate COVID-19 is defined as > 2 of the following in non-intubated patients: any symptom of mild disease, radiographic imaging (chest x-ray or lung ultrasound) with bilateral ground glass opacities or bilateral consolidations, SpO2 <90% up to 5L Nasal Cannula (NC)
• No additional signs or symptoms of severe COVID-19.

You may not qualify if…

• Type 1 Diabetes Mellitus (T1DM) diabetes, as per ADA guidelines
• History of Diabetic Ketoacidosis (DKA)
• History of acute pancreatitis
• Chronic or Acute Renal Failure with Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min/1.73 m2
• Exclusion Criteria:
• T1DM diabetes, as per ADA guidelines, History of DKA, History of acute pancreatitis; Chronic or Acute Renal Failure with eGFR < 30 ml/min/1.73 m2

Where it is running

• University of Miami — Miami, Florida, United States

Full record on ClinicalTrials.gov

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