Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis
Completed · Phase 2
Conditions studied: Glomerulosclerosis, Focal Segmental
In brief
This study will evaluate the efficacy, safety and pharmacokinetics (PK) of VX-147 in participants with apolipoprotein L1 (APOL1)-mediated focal segmental glomerulosclerosis (FSGS).
Key facts
- Study ID
- NCT04340362
- Run by
- Vertex Pharmaceuticals Incorporated
- People needed
- 16
- Starts
- 2020-06-08
- Expected to finish
- 2021-12-09
- Last updated by the study team
- 2025-09-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham - The Kirklin Clinic — Birmingham, Alabama, United States
- California Institute of Renal Research — San Diego, California, United States
- The George Washington University Medical Faculty Associates - Kidney Disease & Hypertension — Washington D.C., District of Columbia, United States
- Howard University Hospital — Washington D.C., District of Columbia, United States
- Kidney and Hypertension Specialists of Miami — Miami, Florida, United States
- Florida Premier Research Institute — Winter Park, Florida, United States
- Morehouse School of Medicine, Grady Memorial Hospital — Atlanta, Georgia, United States
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States
- Georgia Nehphrology — Lawrenceville, Georgia, United States
- Central Georgia Kidney Specialists PC — Macon, Georgia, United States
- Renal Associates of Baton Rouge — Baton Rouge, Louisiana, United States
- Ochsner Medical Center - New Orleans — New Orleans, Louisiana, United States
- Boston Medical Center — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Renal and Transplant Associates of New England, PC — Springfield, Massachusetts, United States
- Paragon Health, PC d/b/a Nephrology Center, PC — Kalamazoo, Michigan, United States
- Nephrology and Hypertension Associates, LTD — Tupelo, Mississippi, United States
- St Louis Kidney Care — St Louis, Missouri, United States
- Nevada Kidney Disease and Hypertension Centers — Las Vegas, Nevada, United States
- SUNY Downstate — Brooklyn, New York, United States
- Urban Family Practice — Buffalo, New York, United States
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
- UNC Kidney Center Division of Nephrology & Hypertension — Chapel Hill, North Carolina, United States
- Tryon Medical Partners — Charlotte, North Carolina, United States
- Durham Nephrology Associates, PA — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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