A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

Completed · Phase 1

Conditions studied: Carcinoma, Hepatocellular, Biliary Tract Cancer, Secondary Liver Cancer, Liver Metastases

In brief

Phase I study of RO7119929 given orally to participants with unresectable advanced or metastatic primary liver cancers and other solid tumors with predominant liver involvement. The primary objective of the study is to explore the safety and to determine the maximum tolerated dose (MTD) and/or optimal biologic dose (OBD) of RO7119929 as single agent.

Key facts

Study ID: NCT04338685
Run by: Hoffmann-La Roche
People needed: 55
Starts: 2020-07-16
Expected to finish: 2023-01-09
Last updated by the study team: 2024-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Histologically confirmed diagnosis of one of the following: unresectable advanced or metastatic HCC (including fibrolamellar HCC) not amenable to a curative treatment approach, unresectable advanced or metastatic intrahepatic or perihilar (Klatskin) BTC not amenable to a curative treatment approach, extrahepatic BTC or gallbladder cancer infiltrating the liver or metastasized into the liver with predominant liver disease, not amenable to a curative treatment approach, metastasized colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), Gastric cancer (GC), renal cell carcinoma (RCC), triple negative breast cancer (TNBC), cutaneous melanoma, or ocular melanoma with predominant liver disease not amenable to a curative treatment approach. Participants with other solid tumors with predominant liver disease not amenable to a curative treatment approach might be enrolled after Sponsor approval
Measurable disease with at least one measurable locally untreated liver lesion, as defined by RECIST v1.1
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Adequate hematologic and major organ functions
Participants for which there is no available standard therapy likely to confer clinical benefit, or participants who are not candidates for such available therapy
Life expectancy of ≥12 weeks, approximated with Royal Marsden Hospital score 0-1 or Gustave Roussy Immune (GRIm) score 0-1. Participants with a Royal Marsden Hospital or GRIm score of ≥2 and a life expectancy of ≥12 weeks according to the investigator's clinical judgement may be enrolled after Medical Monitor approval has been obtained.
For participants with HCC: Child-Pugh score of A6 or better

You may not qualify if…

History or clinical evidence of central nervous system (CNS) primary tumors or metastases including leptomeningeal metastases, unless they have been previously treated, are asymptomatic, and have had no requirement for steroids or enzyme-inducing anticonvulsants in the last 14 days prior to Screening
Evidence of any extra-hepatic primary tumor or metastasis requiring prompt medical intervention
Receipt of prior therapy with a TLR7/8/9 agonist and/or IFN-alpha
Prior chemotherapy, antibody, or other registered or experimental cancer treatment within 3 weeks of study Cycle 1 Day 1. Specifically, no CPI antibody is allowed to be administered within 6 weeks of study Cycle 1 Day 1
Receipt of investigational agent for any other indication within 3 weeks of dosing
Treatment with systemic immunosuppressive medication (including, but not limited to, corticosteroids, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-TNF-alpha agents) within 2 weeks prior to initiation of study treatment, or anticipation of need for systemic immunosuppressive medication during study treatment
Local therapy to liver (e.g. radiofrequency ablation, percutaneuous ethanol or acetic acid injection, cryoablation, high-intensity focused ultrasound, transarterial chemoembolization, and transarterial embolization) within 3 weeks prior to initiation of study treatment, radioembolization within 3 months prior to initiation of study treatment, or non-recovery from side effects of such procedure
Treatment-related toxicities from prior cancer therapy that have not resolved to </= Grade 1 CTC AE prior to study treatment with the exception of the following Grade 2 toxicities:
alopecia, peripheral neuropathy, any laboratory changes that still lie within the inclusion criteria defined above
History of other malignancy within 2 years; exception for ductal carcinoma in situ not requiring chemotherapy, low grade cervical intraepithelial neoplasia (CIN), nonmelanoma skin cancer, low grade localized prostate cancer (Gleason score < Grade 7), or optimally treated Stage 1 uterine cancer.
Active or history of immunologic-mediated disease, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjogren's syndrome or Guillain-Barré syndrome
Known active or uncontrolled bacterial, viral, fungal, mycobacterial, parasitic, or other infection.
Ascites, pleural effusion, or pericardial effusion requiring medical intervention within 12 months prior to study entry.
History of human immunodeficiency virus (HIV) infection
Active hepatitis B virus (HBV) infection
Coinfection of HBV and hepatitis C virus (HCV).

Where it is running

City of Hope Cancer Center — Duarte, California, United States
Rigshospitalet; Onkologisk Klinik — København Ø, Denmark
Queen Mary Hospital; Dept of Medicine — Hong Kong, Hong Kong
Seoul National University Hospital — Seoul, South Korea
Asan Medical Center — Seoul, South Korea
Clínica Universidad de Navarra — Pamplona, Navarre, Spain
Hospital Universitari Vall d'Hebron; Oncology — Barcelona, Spain
Clinica Universidad de Navarra Madrid; Servicio de Oncología — Madrid, Spain
National Taiwan Uni Hospital — Taipei, Taiwan
Tri-Service General Hospital — Taipei, Taiwan

Full record on ClinicalTrials.gov

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