The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function
In brief
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain a potential mechanism that contributes to racial disparities in blood pressure and cardiovascular disease risk. A secondary goal is to determine if mitochondrial reactive oxygen species improves blood pressure and vascular function in individuals with elevated blood pressure and stage 1 hypertension.
Key facts
- Study ID
- NCT04334135
- Run by
- Auburn University
- People needed
- 60
- Starts
- 2020-10-02
- Expected to finish
- 2025-08-31
- Last updated by the study team
- 2024-05-29
Who can join
Age: 19 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Are between the ages of 19-75.
- Have blood pressure no higher than 150/90 mmHg.
- Have a BMI below 35 Kg/m2 (otherwise healthy)
- Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
- Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).
- Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months.
You may not qualify if…
- Known allergy to MitoQ
- High blood pressure - greater the 150/90 mmHg
- Low blood pressure - less than 90/50 mmHg
- History of cardiovascular disease
- History of cancer
- History of diabetes
- History of kidney disease
- Obesity (BMI > 30 kg/m2)
- Smoking or tobacco use
- Current pregnancy
- Nursing mothers
- Communication barriers
Where it is running
- Kinesiology Building — Auburn, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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