Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
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Conditions studied: Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
In brief
Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with heart failure and reduced ejection fraction (HFrEF).
Key facts
- Study ID
- NCT04331769
- Run by
- Ancora Heart, Inc.
- People needed
- 400
- Starts
- 2020-12-21
- Expected to finish
- 2030-12-21
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-years or older
- Ejection Fraction: ≥20% and ≤40% measured by transthoracic echocardiography (TTE) and assessed by an echocardiography (echo) core lab
- LV end-diastolic diameter ≥55 mm measured by TTE and assessed by an echo core lab
- Symptom Status:
- NYHA III,
- NYHA ambulatory IV, or
- NYHA II with a heart failure hospitalization within the prior 12 months (of signing the consent)
- Able to complete six-minute walk test with distance between 100 m and 450 m.
- Diagnosis and treatment for heart failure should be established at least 90 days before the date of consent. Subjects should be on stable, optimally titrated medical therapy for at least 30 days, as recommended according to current guidelines as standard-of-care for Heart Failure therapy, with any intolerance documented.
- "Stable" is defined as no more than a 100% increase or a 50% decrease of total daily doses. Medication changes within this range do not require any additional waiting before the screening assessments
- When a total daily dose increase or decrease exceeds that which is considered stable, the screening TTE and CT will be postponed 30 days after the medication change
- When additional titration is required to optimize a subject's medication that exceeds what is considered stable, the screening TTE and CT will be postponed at least 30 days after achieving the optimal dose (provided the optimal dose remains outside of the stable parameters)
- When a dose-for-dose equivalent change in the class of medication change is made, no additional waiting is required before the screening assessments
- When a change in class medication change exceeds what is considered stable, OR a new class of medication is added, the screening TTE and CT will be postponed 30 days after the medication change
- If an SGLT2 inhibitor is added to a subject's medications, the screening TTE and CT will be postponed at least 30 days after the addition
- If an SGLT2 inhibitor dose changes per the stable definition above, no additional waiting is required before the screening assessments
- If an SGLT2 inhibitor dose change exceeds what is considered stable, the screening TTE and CT will be postponed at least 30 days after achieving the optimal dose (provided the dose remains outside of the stable parameters)
- When applicable, for guideline-directed device-based therapies: a CRT device must be placed > 90 days before the screening TTE and CT, and an ICD must be placed > 30 days before the screening TTE and CT
- Able and willing to complete all qualifying diagnostic and functional tests, willing to accept blood product transfusion if required and agrees to comply with study follow-up schedule
You may not qualify if…
- Cardiovascular
- Myocardial infarction or any percutaneous cardiovascular intervention, cardiovascular surgery, or carotid surgery within 90 days prior to consent
- Untreated clinically significant coronary artery disease (CAD) requiring revascularization
- Fluoroscopic or echocardiographic evidence of severe aortic arch calcification, mobile aortic atheroma, intracardiac mass, thrombus or vegetation
- Suboptimal ventricular anatomy or wall thickness as determined from screening echocardiography and/or CT scan
- Heart failure on the basis other than ischemic or non-ischemic dilated cardiomyopathy (e.g., hypertrophic cardiomyopathy, amyloid cardiomyopathy, restrictive cardiomyopathy, uncorrected congenital heart disease, constrictive pericarditis)
- Hemodynamic instability within 30 days prior to the implant defined as subject requiring inotropic support or mechanical hemodynamic support
- Any planned cardiac surgery or interventions within the next 180 days post-randomization (including therapeutic right heart procedures)
- Active bacterial endocarditis
- Severe RV dysfunction assessed by right heart catheterization (RHC) and/or TTE
- Fixed pulmonary hypertension with PA systolic pressure >70 mmHg not responsive to vasodilator therapy
- History of any stroke within the prior 90 days of consent or documented Modified Rankin Scale ≥ 2 disability from any prior stroke
- Valvular
- Mitral regurgitation grade 3+ (moderate-severe) or 4+ (severe)
- Untreated degenerative (primary) mitral valve disease (mild prolapse with no need for intervention is allowable)
- Prior mitral or aortic valve replacement
- Tricuspid regurgitation grade 4+ (severe)
- Moderate or severe aortic valve stenosis (AVA less than 1.5 cm2 or peak velocity AV Vmax >300 cm/sec)
- Aortic regurgitation grade 2+ (moderate), 3+ (moderate-severe), or 4+ (severe)
- Procedural
- Anatomical pathology or constraints preventing appropriate access/implant of the AccuCinch Ventricular Restoration System (e.g., femoral arteries will not support a 20F Introducer sheath)
- Renal insufficiency (i.e., eGFR of <25 ml/min/1.73 m2)
- Subjects in whom anticoagulation during the procedure is contraindicated
- Subjects in whom 90 days of antiplatelet therapy is contraindicated
- Known allergy to nitinol, polyester, or polyethylene
Where it is running
- Dignity Health St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
- Phoenix Cardiovascular Research Group — Phoenix, Arizona, United States
- Tucson Medical Center — Tucson, Arizona, United States
- University of California San Diego — La Jolla, California, United States
- Scripps Health — La Jolla, California, United States
- University of Southern California — Los Angeles, California, United States
- University of California Irvine Medical Center — Orange, California, United States
- Kaiser Permanente San Francisco — San Francisco, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Hartford Health — Hartford, Connecticut, United States
- Yale University — New Haven, Connecticut, United States
- Medstar Health Research Institute — Washington D.C., District of Columbia, United States
- JFK Medical Center — Atlantis, Florida, United States
- HCA Florida Largo Hospital — Largo, Florida, United States
- University of Miami — Miami, Florida, United States
- Ascension Sacred Heart — Pensacola, Florida, United States
- University of South Florida — Tampa, Florida, United States
- Emory University — Atlanta, Georgia, United States
- Northside Hospital — Atlanta, Georgia, United States
- University of Chicago Medical Center — Chicago, Illinois, United States
- Advocate Good Samaritan Hospital — Downers Grove, Illinois, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- Cardiovascular Research Institute of Kansas — Wichita, Kansas, United States
- University of Kentucky — Lexington, Kentucky, United States
- Grandview Medical Group Research, LLC — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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