The Genomic Medicine at VA Study

Status unconfirmed · Not applicable

Conditions studied: Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer, Breast Cancer, Prostate Cancer

In brief

This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.

Key facts

Study ID

NCT04331535

Run by

Boston VA Research Institute, Inc.

People needed

1076

Starts

2020-07-17

Expected to finish

2025-09-30

Last updated by the study team

2022-10-03

Who can join

Age: 50 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 50-70 years at enrollment
• No known diagnosis of the following conditions, initially screened by the International Classification of Disease (ICD) codes or other electronic health record (EHR) data using validated methods and then confirmed with potential patient-participants during recruitment: coronary artery disease, atrial fibrillation, type 2 diabetes, colorectal cancer, breast cancer, prostate cancer

You may not qualify if…

• Patients will be ineligible if they:
• Have a known diagnosis of at least one of the six diseases of interest
• Are younger than age 50 or older than age 70
• Are pregnant
• Are incarcerated or institutionalized

Where it is running

• VA Boston Healthcare System — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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