Prediction of Outcomes Following Total Knee Replacement- Pilot
Completed · Not applicable
Conditions studied: Osteoarthritis, Knee, Knee Replacement
In brief
This study seeks to examine multiple risk factors as predictors of pain and function following total knee arthroplasty (TKA). Risk factors will be measured pre-surgically using psychophysical testing procedures, multimodal evaluation of sleep, standardized questionnaires. Additionally, this study will collect pilot data on a brief mindfulness-based cognitive-behavioral treatment that may help to improve long-term TKA outcomes. The pilot study compared TKA patients that received brief mindfulness-based cognitive behavioral therapy (MBCBT) to the treatment-as-usual (TAU) group from the parent study.
Key facts
- Study ID
- NCT04328701
- Run by
- Brigham and Women's Hospital
- People needed
- 44
- Starts
- 2018-04-01
- Expected to finish
- 2023-12-30
- Last updated by the study team
- 2026-05-20
Who can join
Age: 45 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 45 or older,
- Meet the American College of Rheumatology criteria for knee OA,
- Scheduled to undergo total knee arthroplasty,
- Facility with the English language that is adequate to complete study procedures
You may not qualify if…
- Cognitive impairment preventing completion of study assessment procedures.
- Myocardial infarction within the past 12 months.
- Presence of Severe Raynaud's or severe neuropathy,
- Active vasculitis or severe peripheral vascular disease,
- Current infection,
- Use of oral steroids,
- Recent history of substance abuse or dependence,
- Known anemia
Where it is running
- Brigham and Women's Hospital Pain Management Center — Chestnut Hill, Massachusetts, United States
Full record on ClinicalTrials.gov
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