The Broken Heart Study II (BHS-II)

Completed · Not applicable

Conditions studied: Takotsubo Cardiomyopathy

In brief

The goals of this study are as follows: 1. To rigorously establish and characterize heterogeneity in the pathophysiology of Takotsubo Syndrome (TS). 2. To rigorously test the contribution of TS triggering events and mental stress responsiveness to 1-year prognosis after TS event.

Key facts

Study ID

NCT04325321

Run by

The Miriam Hospital

People needed

66

Starts

2020-09-02

Expected to finish

2026-02-28

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >=18
• A new diagnosis of takotsubo syndrome fulfilling Mayo Clinic criteria
• Ability to understand and speak English

You may not qualify if…

• Inability or unwillingness to give informed consent
• Severe cognitive impairment
• Uncontrolled hypertension
• Acute psychosis
• High suicidal risk
• Pregnancy
• Poor echocardiographic window
• Conditions that would interfere with adherence to study requirements (e.g., ongoing alcohol or substance abuse)
• If the participant is clinically unstable

Where it is running

• The Miriam Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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