Melatonin and Salt on Blood Vessel Function

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Cardiovascular Risk Factor

In brief

Increased dietary sodium causes increases in oxidative stress and damages blood vessels. Americans eat more than the recommended amount of sodium. Melatonin is a powerful endogenous antioxidant that has reduced oxidative stress levels in clinical and healthy populations. This study will investigate whether melatonin can attenuate the negative effects of sodium on blood vessels.

Key facts

Study ID

NCT04325191

Run by

University of Delaware

People needed

15

Starts

2020-03-12

Expected to finish

2022-09-30

Last updated by the study team

2021-04-28

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy
• normal blood pressure

You may not qualify if…

• hypertension
• heart disease
• diabetes
• kidney disease
• renal impairment
• cancer
• obese (BMI ≥30)
• sleep disorder
• use of tobacco products
• pregnant or breastfeeding
• take any medications for the above conditions
• endurance trained athletes
• night shift worker
• melatonin or antioxidant consumption for the previous 3 months
• use of selective serotonin reuptake inhibitors

Where it is running

• University of Delaware — Newark, Delaware, United States (enrolling)

Full record on ClinicalTrials.gov

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