THRIVE Use in Pediatric Populations- Multi Site
Completed · Not applicable
Conditions studied: Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
In brief
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia. The use of high-flow nasal cannula oxygen supplementation during anesthesia for surgical procedures has been a recent development in the adult population, with limited data analyzing the pediatric population. This study will determine whether high flow nasal cannula oxygen supplementation during surgical or endoscopic procedures can prevent desaturation events in children under anesthesia and improve the outcomes of that surgery.
Key facts
- Study ID
- NCT04322994
- Run by
- Stanford University
- People needed
- 175
- Starts
- 2020-10-21
- Expected to finish
- 2024-01-19
- Last updated by the study team
- 2025-03-27
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Pediatric patients less than 18 years of age undergoing general anesthesia for procedures or surgeries
You may not qualify if…
- Pregnancy
- Absence of parent or legal guardian able to provide written consent for study participation
- Anatomical or surgical contraindications (epistaxis, basilar skull fractures or abnormalities, nasal surgery or obstruction, nasal fractures, nasal vascular abnormalities), tracheostomy tube
- Emergent surgery for which application of HFNC might delay surgery or might result in increased aspiration risk.
Where it is running
- Lucile Packard Children's Hospital Stanford — Palo Alto, California, United States
- Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Massachussetts Eye and Ear Harvard Medical School — Boston, Massachusetts, United States
- Cincinnati Children's Hospital — Cincinnati, Ohio, United States
- The University of Virginia — Charlottesville, Virginia, United States
Full record on ClinicalTrials.gov
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