Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)

Status unconfirmed · Not applicable

Conditions studied: Schizophrenia and Related Disorders

In brief

To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service centers are randomized to one of the two treatments.

Key facts

Study ID

NCT04321759

Run by

Beth Israel Deaconess Medical Center

People needed

378

Starts

2021-06-01

Expected to finish

2026-01-31

Last updated by the study team

2023-11-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 18 to 65;
• DSM-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder (confirmed via the MINI diagnostic interview);
• estimated IQ of > 70 (established via WTAR).

You may not qualify if…

• the presence of a current organic brain syndrome;
• intellectual disability (DSM-5);
• participation in either CET or SST within the prior year.

Where it is running

• Hartford Hospital - Institute of Living — Hartford, Connecticut, United States (enrolling)
• Maine Medical Center — Portland, Maine, United States (enrolling)
• Massachusetts Mental Health Center — Boston, Massachusetts, United States (enrolling)
• UMass Medical School — Worcester, Massachusetts, United States (enrolling)
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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