Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

Recruiting now

Conditions studied: Metabolic Inflexibility

In brief

The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.

Key facts

Study ID

NCT04320264

Run by

East Carolina University

People needed

100

Starts

2020-03-03

Expected to finish

2025-12-01

Last updated by the study team

2025-08-07

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-50 years old
• BMI of 25 - 30 kg/m2
• BMI > 40kg/m2
• Lactate levels in top and lower 25%

You may not qualify if…

• Pregnant women
• Mentally disabled
• Prisoners
• Smokers
• Subjects with heart disease
• Type 1 and 2 diabetes
• Endocrine disease
• Hypertension
• Musculoskeletal disease
• Peripheral occlusion
• Hepatic disease
• Have had weight fluctuations exceeding + 3% in the previous 12 months
• On medications which alter carbohydrate metabolism will not be studied

Where it is running

• East Carolina University — Greenville, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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