Impact of a Yoga Intervention on Pain and Multiomics in Participants With IBS

Completed · Not applicable

Conditions studied: Irritable Bowel Syndrome, Abdominal Pain

In brief

The purpose of this research study is to see if a six-week yoga program delivered online/virtually via Zoom, reduces abdominal pain in people with irritable bowel syndrome (IBS). This study also looks at whether the yoga program changes the composition of microorganisms in the gut and their metabolites, and compares the program in people with IBS versus healthy people (also known as "healthy controls" or "HC"). People in this study are randomized (like flipping a coin) to one of two conditions: half of the people attend the online/virtual private yoga program delivered via Zoom for the first six-weeks, and half of the people wait for six-weeks and then attend the online/virtual private yoga program for six-weeks. The hypothesis of this study is that the practice of yoga induces shifts in the gut microbiota and microbial-derived metabolites, which will correlate with diminished abdominal pain.

Key facts

Study ID

NCT04315714

Run by

University of Maryland, Baltimore

People needed

17

Starts

2021-03-04

Expected to finish

2021-08-24

Last updated by the study team

2021-09-02

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ability to read/write in English
• Access to smartphone/computer/email; Internet and camera access for online/virtual yoga sessions via Zoom
• Physical ability to engage in twice weekly yoga for 6 weeks (60 minutes each session), with physical clearance provided by current healthcare provider
• Diagnosis of IBS and IBS subtype (for cases), with documentation provided by current healthcare provider
• Self-report average, abdominal pain over past 7 days ≥ 3 (for cases: on 0-10 scale)
• Willingness to participate in all study procedures

You may not qualify if…

• Regular yoga practice (past 3 months)
• Recent antibiotic use (past 3 months)
• Consumption of a strict vegan/vegetarian diet
• Plan to initiate prebiotic/synbiotic/probiotic use during study period
• Any medical condition (cardiac, pulmonary, neurological, musculoskeletal, immunological etc.) that would preclude engagement in the yoga intervention
• Any organic gastrointestinal condition (inflammatory bowel disease: Crohn's disease, Ulcerative Colitis, active H. pylori infection, etc.)
• Severe comorbid pain or psychiatric condition requiring recent hospitalization
• Pregnancy, or plans to become pregnant during study period
• Unwilling to participate in study procedures

Where it is running

• University of Maryland, Baltimore, School of Nursing — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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