Comparing Ascites Relief In Two Standard Treatments: Large Volume Paracentesis Vs. Early Tips Using Viatorr Controlled Expansion Stents

Completed · Not applicable

Conditions studied: Hypertension, Portal, Ascites

In brief

For this study, the investigators will be collecting data based on patients' random selection to two different approved standard of care treatments for ascites: Subjects will get randomized into either Group A: Large Volume Paracentesis (LVP) with albumin infusion, or Group B: an early transjugular intrahepatic portosystemic shunt (TIPS) procedure.

Key facts

Study ID

NCT04315571

Run by

University of California, Los Angeles

People needed

68

Starts

2020-03-24

Expected to finish

2026-04-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females > 18 years of age at time of procedure
• First de novo TIPS placement
• Patent internal or external jugular vein
• Willing to provide the hepatology service information for follow up
• No known diagnosis of hypercoagulopathy
• No portal vein thrombosis
• No malignancy (must be a definite diagnosis)
• Patient must provide written informed consent
• Proper clinical indication of TIPS based on American Association for the Study of Liver Diseases (AASLD) guidelines
• Recurrent ascites necessitating at least 2 large volume paracenteses performed within a minimum interval of 3 weeks

You may not qualify if…

• Age <18
• LVP > 6 times in 2 months
• Liver failure (Child Pugh > 12)
• Cardiac failure
• No right jugular venous access
• Absolute TIPS contraindications (e.g. right heart failure, severe encephalopathy, liver failure, pregnant (if possible)).

Where it is running

• UCLA Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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