Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults
Status unconfirmed · Not applicable
Conditions studied: Mild Cognitive Impairment, Exercise Training
In brief
In this research, a unique "Exergame" has been developed and is being tested. The Exergame consists of unique Virtual Reality Cognitive Training (VRCT) games combined with concurrent cycling on a recumbent stationary cycle. The Exergame seamlessly integrates specific cognitive tasks into a virtual environment and is synchronized with cycling to promote cognition. Cycling through an interesting virtual environment will motivate and engage the older adult to participate in the exercise, and VRCT could augment cycling's effects on cognition. A further innovation is that the Exergame has been developed as both an Apple TV and iPAD application, making it widely accessible and available. It will provide a low-cost VRCT Exergame option that currently does not exist, one that is affordable and compatible with almost any stationary cycle. This project is significant because treatment that delays the onset of Alzheimer's Disease (AD) by five years could save the U.S. economy an estimated $89 billion by 2030 and no drugs can yet prevent, cure, or even slow AD. Aerobic exercise and cognitive training are two such promising interventions. Emerging mechanistic studies further suggest that the two interventions together may have a synergistic, superior cognitive effect than either intervention alone. The purpose of this project is to demonstrate the feasibility and efficacy of the Exergame intervention on cognition. An RCT is planned in which subjects are randomized on a 2:1:1 allocation ratio to 3 parallel groups (exergame:cycling only:attention control). Mixed methods will be used to assess outcomes in both phases.
Key facts
- Study ID
- NCT04311736
- Run by
- Moai Technologies LLC
- People needed
- 96
- Starts
- 2019-10-01
- Expected to finish
- 2021-10-01
- Last updated by the study team
- 2020-03-17
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Cognitive complaint (defines as answering yes to the question "Do you feel that your memory or thinking skills have gotten worse recently within the last 2 years?");
- Not engaging in aerobic exercise or cognitive training >2 days/week, 30 minutes a session in the past 3 months;
- Age 65 years and older;
- Written consent.
- Medical clearance to participate in a supervised exercise program
You may not qualify if…
- Resting heart rate > 100 or <50 beats/min with symptoms;
- Dementia or mild cognitive impairment (self-report, diagnosis, or scoring <26 on the Telephone Interview for Cognitive Status;
- Evidence that cognitive decline or memory complaints were caused by underlying neurological or psychiatric disorder or chemical dependency as determined by primary health care provider;
- Current enrollment in another intervention study;
- ACSM contraindications to exercise or other factors that make exercise impossible or unsafe.
Where it is running
- University of Minnesota — Minneapolis, Minnesota, United States (enrolling)
Full record on ClinicalTrials.gov
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