Neuroimaging GABA Physiology in Fragile X Syndrome
Stopped early · Phase 1
Conditions studied: Fragile X Syndrome (FXS), Idiopathic Intellectual Developmental Disorder (IDD)
In brief
The investigators wish to compare the brain distribution of GABA(A) receptors and GABA levels in young adult males with Fragile X Syndrome compared to idiopathic intellectual developmental disorder. The radiopharmaceutical \[18F\]flumazenil has been used to study GABA(A) receptor distribution in other genetic syndromes with autistic features; however, despite overwhelming evidence supporting the importance of the GABAergic system in FXS, no clinical investigation of this system in human FXS has been reported in the literature. Therefore, this study will provide the first in vivo comprehensive examination of the GABAergic system in FXS using hybrid positron emission tomography/ magnetic resonance imaging (PET/MRI).
Key facts
- Study ID
- NCT04308954
- Run by
- Stanford University
- People needed
- 17
- Starts
- 2016-11-01
- Expected to finish
- 2018-12-06
- Last updated by the study team
- 2021-01-28
Who can join
Age: 18 and older, up to 30. Sex: male. Healthy volunteers: not accepted.
Where it is running
- Stanford University — Stanford, California, United States
Full record on ClinicalTrials.gov
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