Analysis of MicroBial Metabolites After Eating Refined Food

Completed · Not applicable

Conditions studied: Dietary Habits

In brief

The purpose of this study is to learn more about what happens in the human body after consuming a meal that contains ultra-processed foods like hamburgers, and if this is different to what happens after consuming a meal that contains lots of whole foods, like fresh vegetables, instead.

Key facts

Study ID

NCT04308473

Run by

The Cleveland Clinic

People needed

46

Starts

2020-09-01

Expected to finish

2026-04-30

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women age 18 years or above.
• Able to provide informed consent and comply with study protocol
• Able to remain on a stable aspirin regimen (either on or off aspirin or aspirin products) for 1 week prior to starting study until the end of the study period.

You may not qualify if…

• Significant chronic illness or end-organ dysfunction, including known history of uncompensated heart failure, renal failure, pulmonary disease, hematologic diseases.
• Active infection or received antibiotics within 6 months of study enrollment.
• Use of over-the-counter probiotic within past month.
• Chronic gastrointestinal disorders.
• Intolerance to probiotic therapy.
• Allergy to vancomycin, ciprofloxacin, neomycin, metronidazole, or lactose.
• Allergy to any of the food components of the challenge meals.
• Having undergone bariatric procedures or surgeries such as gastric banding or bypass.
• Pregnancy.

Where it is running

• Cleveland Clinic Main Campus — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.