Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy

Running, not enrolling

Conditions studied: Cardiotoxicity, Lung Cancer Stage III, Lung Cancer Stage II, Radiation Toxicity

In brief

This observational cohort will evaluate the cardiovascular effects of chemoradiation used to treat locally advanced, non-small cell lung cancer. Patients will be enrolled prior to the start of therapy and followed during and for at least 2 years after therapy with echocardiograms, nuclear stress tests, blood sampling, and quality of life surveys.

Key facts

Study ID

NCT04305613

Run by

Abramson Cancer Center at Penn Medicine

People needed

221

Starts

2020-09-14

Expected to finish

2030-12-01

Last updated by the study team

2025-10-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years of age
• Histologically confirmed or clinically diagnosed non-small cell lung cancer where the plan is for definitive treatment that includes radiation
• Able to give written informed consent

You may not qualify if…

• Pregnant or breast-feeding
• Prior treatment with anthracyclines
• Radiation treatment not expected to involve any heart exposure as determined by treating provider
• ECOG performance status greater than 2
• Vulnerable patients, including pregnant women and prisoners
• Contraindication to rest/vasodilator stress PET/CT, including: asthma with ongoing wheezing at time of enrollment; known Mobitz Type II AV block, 3rd degree AV block, or sick sinus syndrom, without a pacemaker; systolic blood pressure less than 90mmHg; known hypersensitivity to Regadenoson and adenosine; profound sinus bradycardia (heart rate less than 40bpm).

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• The Brigham and Women's Hospital — Boston, Massachusetts, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Rutger's University / Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Lancaster General Hospital — Lancaster, Pennsylvania, United States
• Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Chester County Hospital — West Chester, Pennsylvania, United States

Full record on ClinicalTrials.gov

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