A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

Recruiting now · Phase 2

Conditions studied: Non-small Cell Lung Cancer

In brief

This trial will evaluate the efficacy and safety of various therapies in participants with Stage IB, IIA, IIB, IIIA, or selected IIIB resectable and untreated NSCLC tumors that meet protocol-specified biomarker criteria.

Key facts

Study ID

NCT04302025

Run by

Genentech, Inc.

People needed

99

Starts

2020-11-06

Expected to finish

2030-05-30

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• NSCLC that is clinically T4 by virtue of mediastinal organ invasion or Stage IIIB by virtue of N3 disease
• Any prior therapy for lung cancer, including chemotherapy, targeted therapy, immunotherapy, or radiotherapy, within 2 years
• Participants with prior lung cancer
• Major surgical procedure within 28 days prior to Cycle 1, Day 1
• Malignancies other than the disease under study within 3 years prior to Cycle 1, Day 1, with the exception of participants with a negligible risk of metastasis or death and with expected curative outcome
• Treatment with an investigational agent for any condition within 4 weeks prior to Cycle 1, Day 1
• Participants known to be positive for human immunodeficiency virus (HIV) are excluded if they meet any of the following criteria: cluster of differentiation 4 (CD4)+ T-cell count of <350 cells/microliters (cells/µL); detectable HIV viral load; history of an opportunistic infection within the past 12 months; on stable antiretroviral therapy for <4 weeks
• Severe infection within 4 weeks prior to initiation of study treatment, including but not limited to hospitalization for complications of infections, or any active infection that, in the opinion of the investigator, could impact participant safety
• Pregnant or lactating, or intending to become pregnant during the study

Where it is running

• Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States (enrolling)
• Laura and ISAAC Perlmutter Cancer Center at NYU Langone. — New York, New York, United States (enrolling)
• Columbia University Medical Center — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange — Orange, California, United States (enrolling)
• Ohio State University — Columbus, Ohio, United States (enrolling)
• Yale Cancer Center — New Haven, Connecticut, United States (enrolling)
• Baptist Clinical Research Institute — Memphis, Tennessee, United States (enrolling)
• MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center) — Washington D.C., District of Columbia, United States (enrolling)
• Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
• University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States (enrolling)
• Virginia Cancer Specialists (Fairfax) - USOR — Fairfax, Virginia, United States (enrolling)
• Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States (enrolling)
• Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States (enrolling)
• UC Davis Comprehensive Cancer Center — Sacramento, California, United States (enrolling)
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
• University of Michigan — Ann Arbor, Michigan, United States (enrolling)
• University of California Los Angeles - Jonsson Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Ellis Fischel Cancer Center — Columbia, Missouri, United States (enrolling)
• Siteman Cancer Center - Washington University Medical Campus — St Louis, Missouri, United States (enrolling)
• Seattle Cancer Care Alliance — Seattle, Washington, United States
• City of Hope - Orange County Lennar Foundation Cancer Center — Irvine, California, United States

Full record on ClinicalTrials.gov

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