Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression

Completed · Phase 1

Conditions studied: Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression, Safety Issues

In brief

Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals during the infusion and a 25-minute recovery period afterwards. After a washout period, the experiment will be repeated in each subject (second run). The two runs differ only by presence versus absence of verbal interaction.

Key facts

Study ID

NCT04301895

Run by

University of California, San Francisco

People needed

20

Starts

2019-04-30

Expected to finish

2019-09-03

Last updated by the study team

2020-03-10

Who can join

Age: 20 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• Able to provide informed consent

You may not qualify if…

• Active substance use disorder
• Prior opioid use disorder
• Opioid use within 30 days.

Where it is running

• University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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