Measures of Mitochondria Dysfunction in PD

Status unconfirmed

Conditions studied: Parkinson Disease, Mitochondrial

In brief

This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.

Key facts

Study ID

NCT04300608

Run by

University of Washington

People needed

30

Starts

2020-02-24

Expected to finish

2021-11-01

Last updated by the study team

2020-11-05

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 65-85 years.
• Ability to attend a 3-hour study visit in Seattle, WA.
• Ability to read and speak English.
• Hoehn \& Yahr Stage 2-3. (bilateral disease, not severely disabled.)

You may not qualify if…

• Any contra-indication to magnetic resonance imaging
• A history of epilepsy, stroke, brain surgery, or structural brain disease.
• The presence of other serious illnesses
• Current or recent enrollment in a clinical trial involving an investigational product or device.
• Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baseline study visit.
• Current drug or alcohol use or dependence.
• Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.)
• Acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
• Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.

Where it is running

• University of Washington — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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